Research Articles
The Double-Edged Sword: How APOBEC3 Enzymes Protect Our Cells Yet Fuel Cancer
Explore the dual role of APOBEC3 cytidine deaminases in DNA break repair and cancer promotion - from antiviral defense to cancer mutagenesis.
How a Single Gene Could Predict Your Cancer Treatment Success
Discover how IL-6 genetic variants can predict response to bevacizumab treatment in metastatic colorectal cancer patients.
Episcripts: The Master Code That Shapes Vascular Health and Cancer
Explore how shared epigenetic regulators control gene expression in both vascular biology and cancer development, revealing new therapeutic opportunities.
Beyond the Gene: How Postgenome Medicine is Revolutionizing Our Fight Against Cancer
Explore how postgenome medicine is transforming cancer treatment by moving beyond DNA sequencing to understand cancer as a dynamic, evolving ecosystem.
The Genome's Forbidden Words: How Missing DNA and Protein Sequences Shape Life
Explore the fascinating world of nullomers and nullpeptides - the missing DNA and protein sequences that reveal evolutionary secrets and offer new approaches to cancer detection and treatment.
The MITF Pathway in Melanoma: The Master Switch of Skin Cancer
Explore the role of MITF pathway mutations in melanoma, including phenotype switching, therapeutic resistance, and future research directions.
How a Tiny Genetic Switch Shapes Our Blood and Cancers
Discover how the Fli-1 gene and its Fli-1b isoform regulate blood development and contribute to diseases through alternative promoters and differential splicing.
The Guardian's Gambit: How a Lens Protein Protects Against Cataracts and Cancer
Discover how αB-crystallin, a lens protein, protects against cataracts and cancer by regulating p53 and maintaining genomic stability.
The Genetic Chaos Within: How Chromosomal Instability Drives Melanoma's Deadly Evolution
Explore how chromosomal instability creates genetic chaos in melanoma cells, driving treatment resistance and disease progression through evolutionary mechanisms.
A New Dawn in Mesothelioma Treatment: Immunotherapy Before Surgery
Groundbreaking research on neoadjuvant immune checkpoint blockade for malignant pleural mesothelioma treatment, offering new hope for patients.